Browsing by Author "Sadeh, Naomi"

Now showing 1 - 6 of 6
  • Thumbnail Image
    Item
    Clarifying the synergistic effects of emotion dysregulation and inhibitory control on physical aggression
    (Human Brain Mapping, 2022-07-15) Bounoua, Nadia; Spielberg, Jeffrey M.; Sadeh, Naomi
    Rising rates of violence underscore the need to better understand how systems that regulate distress and impulse control jointly modulate aggression risk. The goals of the current study were to investigate the unique and interactive effects of emotional dysregulation and inhibitory control on the perpetration of physical aggression. We recruited a high-risk community sample of 206 adults (M/SDage = 33.55/10.89 years old; 47.1% female) who reported a range of physically aggressive behaviors. All participants completed a self-report measure (Difficulties in Emotion Regulation Scale), neuropsychological testing (Color Word Interference Test), and clinical interviewing (Lifetime History of Aggression Interview), and a subset of individuals (n = 134) underwent a neuroanatomical scan. As expected, the interplay of emotional and inhibitory control explained unique variance in physical aggression above and beyond their main effects. The positive association between emotion dysregulation and aggression strengthened as inhibitory control decreased. Cortical thickness in two right prefrontal clusters, one that peaked in the superior frontal gyrus and one that peaked in the caudal middle frontal gyrus, was also associated with the interactive effects of emotional dysregulation and inhibitory control. Notably, thickness in the superior frontal gyrus mediated the association between emotion dysregulation and physical aggression at low levels of inhibitory control. Using a multilevel and multimethod approach, the present study revealed neuroanatomical correlates of emotion–cognition interactions that have translational relevance to violence perpetration. These findings extend previous work primarily focused on functional-based neural assessments and point to the utility of examining neuroanatomical correlates of emotion–cognition interactions for understanding human aggression.
  • Thumbnail Image
    Item
    Elevations in Blood Pressure Associated with Exposure to Violence are Mitigated by Pro-gun-Carrying Attitudes among Street-Identified Black Males and Females
    (Journal of Urban Health, 2023-10-13) Payne, Yasser Arafat; Sadeh, Naomi; Hitchens, Brooklynn K.; Bounoua, Nadia
    Living in neighborhoods with elevated rates of violent crime, such as in many poor Black American communities, is a risk factor for a range of physical and mental health challenges. However, the individual different factors that influence health outcomes in these stressful environments remain poorly understood. This study examined relations between exposure to violence, gun-carrying attitudes, and blood pressure in a community sample of street-identified Black American boys/men and girls/women. Survey data and blood pressure were collected from 329 participants (ages 16–54; 57.1% male) recruited from two small urban neighborhoods with high rates of violence using street participatory action research methodology. Results revealed that systolic blood pressure was elevated in the sample as was exposure to severe forms of direct and vicarious violence (e.g., shootings, assault). Attitudes about carrying guns moderated associations between the degree of violence exposure endorsed by participants and both systolic and diastolic blood pressure. Specifically, the positive association between exposure to violence and both systolic and diastolic blood pressure at low levels of pro-gun-carrying attitudes was no longer apparent at high levels of pro-gun attitudes. Furthermore, pro-gun attitudes appeared to moderate the association between exposure to violence and systolic pressure for older participants but not younger participants. Results suggest that positive attitudes about carrying guns (presumably indicative of pro-gun-carrying behavior) weakened the link between violence exposure and blood pressure. These novel findings suggest that carrying a gun may protect against the harmful effects of chronic stress from violence exposure on physical health outcomes (i.e., hypertension) among street-identified Black Americans.
  • Thumbnail Image
    Item
    A multidimensional examination of psychopathy traits and gray matter volume in adults
    (Social Cognitive and Affective Neuroscience, 2021-12-08) Miglin, Rickie; Rodriguez, Samantha; Bounoua, Nadia; Sadeh, Naomi
    Uncovering the neurobiological abnormalities that may contribute to the manifestation of psychopathic traits is an important step toward understanding the etiology of this disorder. Although many studies have examined gray matter volume (GMV) in relation to psychopathy, few have examined how dimensions of psychopathic traits interactively relate to GMV, an approach that holds promise for parsing heterogeneity in neurobiological risk factors for this disorder. The aim of this study was to investigate the affective-interpersonal (Factor 1) and impulsive-antisocial (Factor 2) dimensions of psychopathy in relation to cortical surface and subcortical GMV in a mixed-gender, high-risk community sample with significant justice-system involvement (N = 156, 50.0% men). Cortex-wide analysis indicated that (i) the Factor 1 traits correlated negatively with GMV in two cortical clusters, one in the right rostral middle frontal region and one in the occipital lobe, and (ii) the interaction of the affective-interpersonal and impulsive-antisocial traits was negatively associated with GMV bilaterally in the parietal lobe, such that individuals high on both trait dimensions evidenced reduced GMV relative to individuals high on only one psychopathy factor. An interactive effect also emerged for bilateral amygdalar and hippocampal GMV, such that Factor 1 psychopathic traits were significantly negatively associated with GMV only at high (but not low) levels of Factor 2 traits. Results extend prior research by demonstrating the neurobiological correlates of psychopathy differ based on the presentation of Factor 1 and 2 traits.
  • Thumbnail Image
    Item
    Neurobiological metric of cortical delay discounting differentiates risk for self- and other-directed violence among trauma-exposed individuals
    (Journal of Psychopathology and Clinical Science, 2023-09-07) Sheehan, Ana E.; Bounoua, Nadia; Stumps, Anna; Miglin, Rickie; Huerta, Wendy; Sadeh, Naomi
    Self- and other-directed violence (SDV/ODV) contribute to elevated rates of mortality. Early trauma exposure shows robust positive associations with these forms of violence but alone does not distinguish those at heightened risk for later engagement in SDV/ODV. Novel assessment metrics could aid early identification efforts for individuals with vulnerabilities to violence perpetration. This study examined a novel neurobiological measure of impulsive choice for reward as a potential moderator of associations between childhood trauma exposure and lifetime SDV/ODV. A high-risk community sample of 177 adults (89 men; 50.3%) were assessed for childhood trauma exposure, engagement in SDV (e.g., suicide attempts), and ODV (e.g., assault). A cortical delay discounting (C-DD) measure was created using a multivariate additive model of gray matter thickness across both hemispheres, previously found to be positively associated with susceptibility to impulsivity and externalizing disorders. Childhood trauma exposure was positively associated with ODV and SDV; however, these relationships differed as a function of C-DD. Engagement in ODV increased as scores on C-DD increased, and SDV increased as scores on C-DD decreased. Furthermore, moderation revealed biological sex differences, as the association between childhood trauma and SDV depended on C-DD for women but not for men. Findings from the present work demonstrate that risk conferred by childhood trauma exposure to violence varied as a function of a C-DD. Together, these findings point to the utility of neurobiological markers of impulsive decision-making for differentiating risk for violence among individuals with a history of trauma exposure.
  • Thumbnail Image
    Item
    Reckless Self-destructive Behavior and PTSD in Veterans: The Mediating Role of New Adverse Events
    (Wiley-Blackwell, 2017-06-23) Lusk, Joanna D.; Sadeh, Naomi; Wolf, Erika J.; Miller, Mark W.; Joanna D. Lusk, B.A., Naomi Sadeh, Ph.D., Erika J. Wolf, Ph.D., & Mark W. Miller, Ph.D.; Sadeh, Naomi
    The addition of self-destructive and reckless behavior as a symptom of posttraumatic stress disorder (PTSD) in DSM-5 has stimulated renewed interest in understanding relationships between these behaviors and trauma-related psychopathology. This study examined the relationship between reckless and self-destructive behaviors (RSDB), intervening exposure to new adverse events, and later PTSD severity in a sample of traumaexposed veterans. At baseline, participants were assessed for RSDB (past 5 years) and current PTSD severity (N = 222). PTSD severity was then reassessed approximately 4 years later (N = 148). Overall, RSDB were reported by 74.4% of the sample, with 61.3% engaging in multiple forms of RSDB. The most commonly endorsed behaviors included alcohol/drug abuse (42.8%), driving while intoxicated (29.4%), gambling (24.7%), and aggression (23.1%). There was a positive correlation between RSDB and PTSD severity at both the baseline (r = .16, p = .031) and follow-up assessment (r = .24, p = .005). Path models indicated that exposure to new adverse events fully mediated the effect of Time 1 RSDB on PTSD symptoms at Time 2 (indirect association: β = .05, p =.046). Results suggest that RSDB are common among trauma-exposed veterans and may perpetuate PTSD symptoms by increasing exposure to new adverse events.
  • Thumbnail Image
    Item
    Trait dimensions of anticipatory and consummatory reward relate differently to self-injurious thoughts and behaviors in a community adult sample
    (Journal of Affective Disorders Reports, 2024-04-26) Huerta, Wendy; Bounoua, Nadia; Sadeh, Naomi
    Background Self-injurious thoughts and behaviors (SITBs) are a major problem worldwide and continue to be a serious public health concern. Research investigating risk factors for suicide has shown that reward processes, such as the inability to feel pleasure, may confer risk for SITBs. However, less work has examined how different dimensions of trait reward relate to SITBs. Accordingly, the present study investigated the unique and interactive effects of trait anticipatory and consummatory reward for explaining SITBs. Methods 260 community adults ages 18–55 (M/SD = 32.79/10.54, females = 49.6 %, males = 50.4 %) completed an interview, neuropsychological tests, and questionnaires. We used hierarchical multivariate multiple regression analysis to assess cross-sectional associations between trait anticipatory and consummatory reward and different types of SITBs [self-injurious thoughts, nonsuicidal self-injury (NSSI), and suicide attempts] from the Risky, Impulsive, and Self-destructive Behavior Questionnaire. Results The unique variance associated with anticipatory and consummatory reward were differentially related to self-injurious thoughts but unrelated to self-injurious behaviors (NSSI/suicide attempts). The interaction of anticipatory and consummatory reward was associated with self-injurious behavior, such that the inability to experience both anticipatory and consummatory reward was associated with higher frequency of NSSI. Limitations Limitations of the study include its cross-sectional nature and reliance on self-reported measures. Conclusions Low anticipatory reward and high consummatory reward may confer risk for self-injurious thoughts. Low levels of both trait anticipatory and consummatory reward may confer risk for NSSI. Findings suggest reward sensitivity may be an understudied risk factor for a range of SITBs.