University of Delaware Open Access Articles

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The University of Delaware Open Access Articles collection consists of scholarly articles written by University of Delaware-affiliated authors. These articles were added in compliance with the University of Delaware Open Access policy passed unanimously by the Faculty Senate April 6, 2015.

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    Matching Interventions to Reading Needs: A Case for Differentiation
    (International Literacy Association, 2016-08-11) Jones, Jill S.; Conradi, Kristin; Amendum, Steven J.; Jill S. Jones, Kristin Conradi, Steven J. Amendum; Amendum, Steven J.
    The purpose of this article is to highlight the importance of providing reading interventions that are differentiated and aligned with an individual student’s most foundational reading need. The authors present profiles of different readers and suggest three principal areas for support: decoding words, reading at an appropriate rate, and comprehending text. In addition to describing differentiated interventions, related classroom instructional techniques are also recommended.
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    Self-weighing behavior in individuals with eating disorders
    (John Wiley & Sons, Inc, 2016-03-18) Pacanowski, Carly R.; Pisetsky, Emily M.; Berg, Kelly C.; Crosby, Ross D.; Crow, Scott J.; Linde, Jennifer A.; Mitchell, James E.; Engel, Scott G.; Klein, Marjorie H.; Smith, Tracey L.; Le Grange, Daniel; Wonderlich, Stephen A.; Peterson, Carol B.; Carly R. Pacanowski, Emily M. Pisetsky, Kelly C. Berg, Ross D. Crosby, Scott J. Crow, Jennifer A. Linde, James E. Mitchell, Scott G. Engel, Marjorie H. Klein, Tracey L. Smith, Daniel Le Grange, Stephen A. Wonderlich, Carol B. Peterson; Pacanowski, Carly R.
    Objective To describe the frequency of self-weighing and reactions to prescribed weekly weighing among individuals with eating disorder (ED) diagnoses, and to compare individuals weighing more or less frequently on mass index (BMI) and the Eating Disorder Examination (EDE) subscales. Method Baseline EDE and demographics from five studies (N = 758). Results Self-weighing was most frequent among individuals with anorexia nervosa (AN), followed by those with bulimia nervosa (BN) and binge eating disorder (BED). On average, participants reacted moderately negative to prescribed weekly weighing. No relationship between weighing frequency and BMI was evident in any sample. There was indication of greater pathology (i.e., restraint, shape concern, weight concern, global) in AN with more frequent weighing. In BN, mixed evidence emerged to support a relationship between more frequent weighing and higher shape concern, weight concern, and global score. In BED, higher restraint was found in those who weighed versus those who did not. Discussion Weighing frequency in each eating disorder (ED) sample was to some extent associated with greater ED severity, but not BMI. Future research should examine relationships between self-weighing, reactions to changing weighing frequency, and ED symptomatology in both ED and non-ED groups to understand the impact of self-weighing in heterogeneous populations.
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    Tsunamis caused by submarine slope failures along western Great Bahama Bank
    (Nature Publishing Group, 2016-11-04) Schnyder, Jara S.D.; Eberli, Gregor P.; Kirby, James T.; Shi, Fengyan; Tehranirad, Babak; Mulder, Thierry; Ducassou, Emmanuelle; Hebbeln, Dierk; Wintersteller, Paul; Jara S.D. Schnyder, Gregor P. Eberli, James T. Kirby, Fengyan Shi, Babak Tehranirad, Thierry Mulder, Emmanuelle Ducassou, Dierk Hebbeln & Paul Wintersteller; Kirby, James T.; Shi, Fengyan; Tehranirad, Babak
    Submarine slope failures are a likely cause for tsunami generation along the East Coast of the United States. Among potential source areas for such tsunamis are submarine landslides and margin collapses of Bahamian platforms. Numerical models of past events, which have been identified using high-resolution multibeam bathymetric data, reveal possible tsunami impact on Bimini, the Florida Keys, and northern Cuba. Tsunamis caused by slope failures with terminal landslide velocity of 20 ms−1 will either dissipate while traveling through the Straits of Florida, or generate a maximum wave of 1.5 m at the Florida coast. Modeling a worst-case scenario with a calculated terminal landslide velocity generates a wave of 4.5 m height. The modeled margin collapse in southwestern Great Bahama Bank potentially has a high impact on northern Cuba, with wave heights between 3.3 to 9.5 m depending on the collapse velocity. The short distance and travel time from the source areas to densely populated coastal areas would make the Florida Keys and Miami vulnerable to such low-probability but high-impact events.
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    Thermal transport across metal silicide-silicon interfaces: An experimental comparison between epitaxial and nonepitaxial interfaces
    (American Physical Society, 2017-02-22) Ye, Ning; Feser, Joseph P.; Sadasivam, Sridhar; Fisher, Timothy S.; Wang, Tianshi; Ni, Chaoying; Janotti, Anderson; Ning Ye, Joseph P. Feser, Sridhar Sadasivam, Timothy S. Fisher, Tianshi Wang, Chaoying Ni, and Anderson Janotti; Ye, Ning; Feser, Joseph P.; Wang, Tianshi; Ni, Chaoying; Janotti, Anderson
    Silicides are used extensively in nano- and microdevices due to their low electrical resistivity, low contact resistance to silicon, and their process compatibility. In this work, the thermal interface conductance of TiSi2, CoSi2, NiSi, and PtSi are studied using time-domain thermoreflectance. Exploiting the fact that most silicides formed on Si(111) substrates grow epitaxially, while most silicides on Si(100) do not, we study the effect of epitaxy, and show that for a wide variety of interfaces there is no dependence of interface conductance on the detailed structure of the interface. In particular, there is no difference in the thermal interface conductance between epitaxial and nonepitaxial silicide/silicon interfaces, nor between epitaxial interfaces with different interface orientations.While these silicide-based interfaces yield the highest reported interface conductances of any known interface with silicon, none of the interfaces studied are found to operate close to the phonon radiation limit, indicating that phonon transmission coefficients are nonunity in all cases and yet remain insensitive to interfacial structure. In the case of CoSi2, a comparison ismade with detailed computational models using (1) full-dispersion diffuse mismatch modeling (DMM) including the effect of near-interfacial strain, and (2) an atomistic Green’ function (AGF) approach that integrates near-interface changes in the interatomic force constants obtained through density functional perturbation theory. Above 100 K, the AGF approach significantly underpredicts interface conductance suggesting that energy transport does not occur purely by coherent transmission of phonons, even for epitaxial interfaces. The full-dispersion DMM closely predicts the experimentally observed interface conductances for CoSi2, NiSi, and TiSi2 interfaces, while it remains an open question whether inelastic scattering, cross-interfacial electron-phonon coupling, or other mechanisms could also account for the high-temperature behavior. The effect of degenerate semiconductor dopant concentration onmetal-semiconductor thermal interface conductance was also investigated with the result that we have found no dependencies of the thermal interface conductances up to (n or p type) ≈1 × 1019 cm−3, indicating that there is no significant direct electronic transport and no transport effects that depend on long-range metal-semiconductor band alignment.
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    Universal dependence of hydrogen oxidation and evolution reaction activity of platinum-group metals on pH and hydrogen binding energy
    (American Association for the Advancement of Science, 2016-01-14) Zheng, Jie; Sheng, Wenchao; Zhuang, Zhongbin; Xu, Bingjun; Yan, Yushan; Jie Zheng, Wenchao Sheng, Zhongbin Zhuang, Bingjun Xu, Yushan Yan; Zheng, Jie; Zhuang, Zhongbin; Xu, Bingjun; Yan, Yushan
    Understanding how pH affects the activity of hydrogen oxidation reaction (HOR) and hydrogen evolution reaction (HER) is key to developing active, stable, and affordable HOR/HER catalysts for hydroxide exchange membrane fuel cells and electrolyzers. A common linear correlation between hydrogen binding energy (HBE) and pH is observed for four supported platinum-group metal catalysts (Pt/C, Ir/C, Pd/C, and Rh/C) over a broad pH range (0 to 13), suggesting that the pH dependence of HBE is metal-independent. A universal correlation between exchange current density and HBE is also observed on the four metals, indicating that they may share the same elementary steps and rate-determining steps and that the HBE is the dominant descriptor for HOR/HER activities. The onset potential of CO stripping on the four metals decreases with pH, indicating a stronger OH adsorption, which provides evidence against the promoting effect of adsorbed OH on HOR/HER.
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    Mantle Sulfides and their Role in Re–Os and Pb Isotope Geochronology
    (Mineralogical Society of America, 2015-12-14) Harvey, Jason; Warren, Jessica M.; Shirey, Steven B.; Jason Harvey, Jessica M. Warren, Steven B. Shirey; Warren, Jessica M.
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    Why We Move: Social Mobility Behaviors of Non-Disabled and Disabled Children across Childcare Contexts
    (Frontiers Media, 2016-09-21) Logan, Samuel W.; Ross, Samantha Mae; Schreiber, Melynda A.; Feldner, Heather A.; Lobo, Michele A.; Catena, Michele A.; MacDonald, Megan; Galloway, James C.; Samuel W. Logan, Samantha Mae Ross, Melynda A. Schreiber, Heather A. Feldner, Michele A. Lobo, Michele A. Catena, Megan MacDonald and James C. Galloway; Lobo, Michele A.; Galloway, James C.
    Background Social mobility is defined as the co-occurrence of self-directed locomotion and direct peer interaction. Social mobility is a product of dynamic child–environment interactions and thus likely to vary across contexts (e.g., classroom, gymnasium, and playground). Purpose The purpose of this present study was to examine differences in children’s social mobility: (1) across contexts by age and (2) between non-disabled and disabled children. Method Participants (n = 55 non-disabled and three disabled children; Mage = 3.1 years, SD = 1.4) were video recorded within a university-based early learning center. Children were recorded for 20 min in each context: classroom, gymnasium, and playground. A 15-s momentary time sampling method was used to code social mobility, the simultaneous occurrence of self-directed locomotion, and direct peer interaction. This variable was calculated as percent time within each context. Results A planned Friedman’s rank ANOVA (n = 55), stratified by age, indicated that older children (3–5 years old) differed across contexts in their social mobility [χ2(2) ~ 7.3–10.5, p < 0.025], whereas younger children (1–2 years old) were similar across contexts. Social mobility was significantly lower in the classroom compared with the playground and gymnasium (with no difference between the latter contexts) for older children. Visual analysis confirmed that disabled children (n = 3) engaged in substantially less time in social mobility (average 0–1%), compared with non-disabled, age-similar peers (2–3 years old average 1–12%) across all contexts. Conclusion A substantial gap exists between non-disabled and disabled children for social mobility. There is an increase in magnitude and variability of social mobility around age three that suggests the gap between non-disabled and disabled children will continue to widen.
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    Editorial: Gut Health: The New Paradigm in Food Animal Production
    (Frontiers Media S.A, 2016-08-31) Kogut, Michael H.; Arsenault, Ryan J.; Michael H. Kogut and Ryan J. Arsenault; Arsenault, Ryan J.
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    Experimental characterization of tensile properties of epoxy resin by using micro-fiber specimens
    (Sage Publications, 2016-09-21) Misumi, Jun; Ganesh, Raja; Sockalingam, Subramani; Gillespie, John W. Jr.; Jun Misumi, Raja Ganesh, Subramani Sockalingam, John W Gillespie; Misumi, Jun; Ganesh, Raja; Sockalingam, Subramani; Gillespie, John W. Jr
    In unidirectional carbon fiber-reinforced plastic laminates, the distance between fibers can varies from submicron to micron length scales. The mechanical properties of the matrix at this length scale are not well understood. In this study, processing methods have been developed to produce high quality epoxy micro-fibers with diameters ranging from 100 to 150 µm that are used for tensile testing. Five types of epoxy resin systems ranging from standard DGEBA to high-crosslink TGDDM and TGMAP epoxy systems have been characterized. Epoxy macroscopic specimens with film thickness of 3300 µm exhibited brittle behavior (1.7 to 4.9% average failure strain) with DGEBA resin having the highest failure strain level. The epoxy micro-fiber specimens exhibited significant ductile behavior (20 to 42% average failure strain) with a distinct yield point being observed in all five resin systems. In addition, the ultimate stress of the highly cross-linked TGDDM epoxy fiber exceeded the bulk film properties by a factor of two and the energy absorption was over 50 times greater on average. The mechanism explaining the dramatic difference in properties is discussed and is based on size effects (the film volume is about 2000 times greater than the fiber volume within the gage sections) and surface defects. Based on the findings presented in this paper, the microscale fiber test specimens are recommended and provide more realistic stress–strain response for describing the role of the matrix in composites at smaller length scales.
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    Lattice Boltzmann approach for hydro-acoustic waves generated by tsunamigenic sea bottom displacement
    (Elsevier, 2016-09-23) Prestininzi, P.; Abdolali, A.; Montessori, A.; Kirby, J. T.; La Rocca, M.; P. Prestininzi, A. Abdolali, A. Montessori, J. T. Kirby, M. La Rocca; Abdolali, A.
    Tsunami waves are generated by sea bottom failures, landslides and faults. The concurrent generation of hydro-acoustic waves (HAW), which travel much faster than the tsunami, has received much attention, motivated by their possible exploitation as precursors of tsunamis. This feature makes the detection of HAW particularly well-suited for building an early-warning system. Accuracy and efficiency of the modelling approaches for HAW thus play a pivotal role in the design of such systems. Here, we present a Lattice Boltzmann Method (LBM) for the generation and propagation of HAW resulting from tsunamigenic ground motions and verify it against commonly employed modelling solutions. LBM is well known for providing fast and accurate solutions to both hydrodynamics and acoustics problems, thus it naturally becomes a candidate as a comprehensive computational tool for modelling generation and propagation of HAW.
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    Evidence for chemically heterogeneous Arctic mantle beneath the Gakkel Ridge
    (Elsevier, 2015-12-07) D’Errico, Megan E.; Warren, Jessica M.; Godard, Marguerite; Megan E. D’Errico, Jessica M. Warren, Marguerite Godard; Warren, Jessica M.
    Ultraslow spreading at mid-ocean ridges limits melting due to on-axis conductive cooling, leading to the prediction that peridotites from these ridges are relatively fertile. To test this, we examined abyssal peridotites from the Gakkel Ridge, the slowest spreading ridge in the global ocean ridge system. Major and trace element concentrations in pyroxene and olivine minerals are reported for 14 dredged abyssal peridotite samples from the Sparsely Magmatic (SMZ) and Eastern Volcanic (EVZ) Zones. We observe large compositional variations among peridotites from the same dredge and among dredges in close proximity to each other. Modeling of lherzolite trace element compositions indicates varying degrees of non-modal fractional mantle melting, whereas most harzburgite samples require open-system melting involving interaction with a percolating melt. All peridotite chemistry suggests significant melting that would generate a thick crust, which is inconsistent with geophysical observations at Gakkel Ridge. The refractory harzburgites and thin overlying oceanic crust are best explained by low present-day melting of a previously melted heterogeneous mantle. Observed peridotite compositional variations and evidence for melt infiltration demonstrates that fertile mantle components are present and co-existing with infertile mantle components. Melt generated in the Gakkel mantle becomes trapped on short length-scales, which produces selective enrichments in very incompatible rare earth elements. Melt migration and extraction may be significantly controlled by the thick lithosphere induced by cooling at such slow spreading rates. We propose the heterogeneous mantle that exists beneath Gakkel Ridge is the consequence of ancient melting, combined with subsequent melt percolation and entrapment.
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    Brain Activation in the Prefrontal Cortex during Motor and Cognitive Tasks in Adults
    (Scientific Research Publishing, 2016-11-03) Liang, Ling-Yin; Shewokis, Patricia A.; Getchell, Nancy; Ling-Yin Liang, Patricia A. Shewokis, Nancy Getchell; Getchell, Nancy
    The prefrontal cortex (PFC) plays an important role in cognitive function, involved in Executive Functions (EFs) such as planning, working memory, and inhibition. Activation in the PFC also occurs during some motor activities. One commonly used tool to assess EF is the Tower of Hanoi, demonstrating sensitivity to PFC dysfunction. However, limited neuroimaging evidence is available to support the contribution of the PFC in the Tower of Hanoi task. In the current study, we use functional near infrared (fNIR) spectroscopy to examine hemodynamic responses associated with neural activity in the PFC in adults as they participate in the Tower of Hanoi task. We compared changes in cerebral oxygenation during resting, a motor task (tapping), and the Tower of Hanoi in 16 neurotypical adults, with measures of relative changes in concentration of oxygenated hemoglobin (Δoxy-Hb) and deoxygenated hemoglobin (Δdeoxy-Hb) taken throughout tasks, as well as total hemoglobin (ΔHbT) and oxygenation (Δoxy). Performance on the Tower of Hanoi was measured by the number of moves used to complete each level and the highest level of successful performance (3, 4, or 5 disks). We found a significant higher value of Δoxy-Hb and Δoxy in dorsolateral PFC (DLPFC) during the Tower of Hanoi as compared to tapping and resting. Significant changes in Δdeoxy-Hb and ΔHbT during the Tower of Hanoi were found in the right DLPFC only. These results support the notion that the Tower of Hanoi task requires higher levels of PFC activity than a similar motor task with low executive function demands.
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    Control Strategy of Maximum Vertical Jumps: the Preferred Countermovement Depth May Not Be Fully Optimized for Jump Height
    (De Gruyter Open, 2016-09-10) Mandic, Radivoj; Knezevic, Olivera M.; Mirkov, Dragan M.; Jaric, Slobodan; Radivoj Mandic, Olivera M. Knezevic, Dragan M. Mirkov, Slobodan Jaric; Jaric, Slobodan
    The aim of the present study was to explore the control strategy of maximum countermovement jumps regarding the preferred countermovement depth preceding the concentric jump phase. Elite basketball players and physically active non-athletes were tested on the jumps performed with and without an arm swing, while the countermovement depth was varied within the interval of almost 30 cm around its preferred value. The results consistently revealed 5.1-11.2 cm smaller countermovement depth than the optimum one, but the same difference was more prominent in non-athletes. In addition, although the same differences revealed a marked effect on the recorded force and power output, they reduced jump height for only 0.1-1.2 cm. Therefore, the studied control strategy may not be based solely on the countermovement depth that maximizes jump height. In addition, the comparison of the two groups does not support the concept of a dual-task strategy based on the trade-off between maximizing jump height and minimizing the jumping quickness that should be more prominent in the athletes that routinely need to jump quickly. Further research could explore whether the observed phenomenon is based on other optimization principles, such as the minimization of effort and energy expenditure. Nevertheless, future routine testing procedures should take into account that the control strategy of maximum countermovement jumps is not fully based on maximizing the jump height, while the countermovement depth markedly confound the relationship between the jump height and the assessed force and power output of leg muscles.
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    Prohibitin involvement in the generation of mitochondrial superoxide at complex I in human sperm
    (Wiley-Blackwell, 2016-08-25) Chai, Ran-Ran; Chen, Guo-Wu; Shi, Hui-Juan; Martin-DeLeon, Patricia A; Chen, Hong; Wai-Sum, O; Ran-Ran Chai; Guo-Wu Chen; Hui-Juan Shi; Wai-Sum O; Patricia A. Martin-DeLeon; Hong Chen; Martin-DeLeon, Patricia A
    Prohibitin (PHB), a major mitochondrial membrane protein, has been shown earlier in our laboratoryto regulate sperm motility via an alteration in mitochondrial membrane potential (MMP) in infertile men with poor sperm quality. To test if PHB expression is associated with sperm mitochondrial superoxide (mROS) levels, here we examined sperm mROS levels, high MMP and lipid peroxidation in infertile men with poor sperm motility (asthenospermia, A) and/or low sperm concentrations (oligoasthenospermia, OA). The diaphorase-type activity of sperm mitochondrial complex I (MCI) and PHB expression were also determined. We demonstrate that mROS and lipid peroxidation levels are significantly higher in sperm from A and OA subjects than in normospermic subjects, whereas high MMP and PHB expression are significantly lower. A positive correlation between mROS and lipid peroxidation and a negative correlation of mROS with PHB expression, high MMP, and sperm motility were found in these subjects. The finding of similar diaphorase-type activity levels of sperm MCI in the three groups studied suggests that the catalytic subunits of MCI in the matrix arm may produce mROS on its own. There may be a dysfunction of electron transport at MCI associated with decreased expression of PHB in sperm with poor quality. We conclude that mROS level is increased and associated with decreased PHB expression, and it may regulate sperm motility via increases in low MMP and lipid peroxidation. This is the first report on the involvement of PHB in human sperm motility loss associated with increased generation of mROS at MCI.
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    High-Throughput Resequencing of Maize Landraces at Genomic Regions Associated with Flowering Time
    (Public Library of Science, 2017-01-03) Jamann, Tiffany M; Sood, Shilpa; Wisser, Randall J; Holland, James B; Tiffany M. Jamann; Shilpa Sood; Randall J. Wisser; James B. Holland; Wisser, RJ
    Despite the reduction in the price of sequencing, it remains expensive to sequence and assemble whole, complex genomes of multiple samples for population studies, particularly for large genomes like those of many crop species. Enrichment of target genome regions coupled with next generation sequencing is a cost-effective strategy to obtain sequence information for loci of interest across many individuals, providing a less expensive approach to evaluating sequence variation at the population scale. Here we evaluate amplicon-based enrichment coupled with semiconductor sequencing on a validation set consisting of three maize inbred lines, two hybrids and 19 landrace accessions. We report the use of a multiplexed panel of 319 PCR assays that target 20 candidate loci associated with photoperiod sensitivity in maize while requiring 25 ng or less of starting DNA per sample. Enriched regions had an average on-target sequence read depth of 105 with 98% of the sequence data mapping to the maize ‘B73’ reference and 80% of the reads mapping to the target interval. Sequence reads were aligned to B73 and 1,486 and 1,244 variants were called using SAMtools and GATK, respectively. Of the variants called by both SAMtools and GATK, 30% were not previously reported in maize. Due to the high sequence read depth, heterozygote genotypes could be called with at least 92.5% accuracy in hybrid materials using GATK. The genetic data are congruent with previous reports of high total genetic diversity and substantial population differentiation among maize landraces. In conclusion, semiconductor sequencing of highly multiplexed PCR reactions is a cost-effective strategy for resequencing targeted genomic loci in diverse maize materials.
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    Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides
    (Public Library of Science, 2017-01-04) Rivera-Torres, Natalia; Banas, Kelly; Bialk, Pawel; Bloh, Kevin M.; Kmiec, Eric B.; Kelly Banas; Pawel Bialk; Kevin M. Bloh; Eric B. Kmiec; Natalia Rivera-Torres; Kmiec, Eric
    CRISPR/Cas9 and single-stranded DNA oligonucleotides (ssODNs) have been used to direct the repair of a single base mutation in human genes. Here, we examine a method designed to increase the precision of RNA guided genome editing in human cells by utilizing a CRISPR/Cas9 ribonucleoprotein (RNP) complex to initiate DNA cleavage. The RNP is assembled in vitro and induces a double stranded break at a specific site surrounding the mutant base designated for correction by the ssODN. We use an integrated mutant eGFP gene, bearing a single base change rendering the expressed protein nonfunctional, as a single copy target in HCT 116 cells. We observe significant gene correction activity of the mutant base, promoted by the RNP and single-stranded DNA oligonucleotide with validation through genotypic and phenotypic readout. We demonstrate that all individual components must be present to obtain successful gene editing. Importantly, we examine the genotype of individually sorted corrected and uncorrected clonally expanded cell populations for the mutagenic footprint left by the action of these gene editing tools. While the DNA sequence of the corrected population is exact with no adjacent sequence modification, the uncorrected population exhibits heterogeneous mutagenicity with a wide variety of deletions and insertions surrounding the target site. We designate this type of DNA aberration as on-site mutagenicity. Analyses of two clonal populations bearing specific DNA insertions surrounding the target site, indicate that point mutation repair has occurred at the level of the gene. The phenotype, however, is not rescued because a section of the single-stranded oligonucleotide has been inserted altering the reading frame and generating truncated proteins. These data illustrate the importance of analysing mutagenicity in uncorrected cells. Our results also form the basis of a simple model for point mutation repair directed by a short single-stranded DNA oligonucleotides and CRISPR/Cas9 ribonucleoprotein complex
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    Audio-Visual Perception of Gender by Infants Emerges Earlier for Adult-Directed Speech
    (PUBLIC LIBRARY SCIENCE, 2017-01-06) Richoz, Anne-Raphaëlle; Quinn, Paul C.; de Boisferon, Anne Hillairet; Berger, Carole; Loevenbruck, Hélène; Lewkowicz, David J.; Lee, Kang; Dole, Marjorie; Caldara, Roberto; Pascalis, Olivier; Anne-Raphaelle Richoz; Paul C. Quinn; Anne Hillairet de Boisferon; Carole Berger; Helène Loevenbruck; David J. Lewkowicz; Kang Lee; Marjorie Dole; Roberto Caldara; Olivier Pascalis; Quinn, Paul C.
    Early multisensory perceptual experiences shape the abilities of infants to perform sociallyrelevant visual categorization, such as the extraction of gender, age, and emotion from faces. Here, we investigated whether multisensory perception of gender is influenced by infant-directed (IDS) or adult-directed (ADS) speech. Six-, 9-, and 12-month-old infants saw side-by-side silent video-clips of talking faces (a male and a female) and heard either a soundtrack of a female or a male voice telling a story in IDS or ADS. Infants participated in only one condition, either IDS or ADS. Consistent with earlier work, infants displayed advantages in matching female relative to male faces and voices. Moreover, the new finding that emerged in the current study was that extraction of gender from face and voice was stronger at 6 months with ADS than with IDS, whereas at 9 and 12 months, matching did not differ for IDS versus ADS. The results indicate that the ability to perceive gender in audiovisual speech is influenced by speech manner. Our data suggest that infants may extract multisensory gender information developmentally earlier when looking at adults engaged in conversation with other adults (i.e., ADS) than when adults are directly talking to them (i.e., IDS). Overall, our findings imply that the circumstances of social interaction may shape early multisensory abilities to perceive gender.
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    A subwavelength resolution microwave/6.3 GHz camera based on a metamaterial absorber
    (Nature Publishing Group, 2017-01-10) Xie, Yunsong; Fan, Xin; Chen, Yunpeng; Wilson ., Jeffrey D; Simons, Rainee N; Xiao, John Q.; Yunsong Xie; Xin Fan; Yunpeng Chen; Jeffrey D.Wilson; Rainee N. Simons; John Q. Xiao; Xie, Yunsong; Chen, Yunpeng; Xiao, John Q
    The design, fabrication and characterization of a novel metamaterial absorber based camera with subwavelength spatial resolution are investigated. The proposed camera is featured with simple and lightweight design, easy portability, low cost, high resolution and sensitivity, and minimal image interference or distortion to the original field distribution. The imaging capability of the proposed camera was characterized in both near field and far field ranges. The experimental and simulated near field images both reveal that the camera produces qualitatively accurate images with negligible distortion to the original field distribution. The far field demonstration was done by coupling the designed camera with a microwave convex lens. The far field results further demonstrate that the camera can capture quantitatively accurate electromagnetic wave distribution in the diffraction limit. The proposed camera can be used in application such as non-destructive image and beam direction tracer.
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    Enzyme I facilitates reverse flux from pyruvate to phosphoenolpyruvate in Escherichia coli
    (Nature Publishing Group, 2017-01-27) Long, Christopher P; Au, Jennifer; Sandoval, Nicholas R; Gebreselassie, Nikodimos A; Antoniewicz, Maciek R; Christopher P. Long; Jennifer Au; Nicholas R. Sandoval; Nikodimos A. Gebreselassie; Maciek R. Antoniewicz; Antoniewicz, Maciej Robert
    The bacterial phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS) consists of cascading phosphotransferases that couple the simultaneous import and phosphorylation of a variety of sugars to the glycolytic conversion of phosphoenolpyruvate (PEP) to pyruvate. As the primary route of glucose uptake in E. coli, the PTS plays a key role in regulating central carbon metabolism and carbon catabolite repression, and is a frequent target of metabolic engineering interventions. Here we show that Enzyme I, the terminal phosphotransferase responsible for the conversion of PEP to pyruvate, is responsible for a significant in vivo flux in the reverse direction (pyruvate to PEP) during both gluconeogenic and glycolytic growth. We use 13C alanine tracers to quantify this back-flux in single and double knockouts of genes relating to PEP synthetase and PTS components. Our findings are relevant to metabolic engineering design and add to our understanding of gene-reaction connectivity in E. coli.
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    Decide Your Time A Randomized Trial of a Drug Testing and Graduated Sanctions Program for Probationers
    (Wiley, 2016-11-11) O'Connell, Daniel J.; Brent, John J.; Visher, Christy A.; Daniel J. O'Connell, John J. Brent, Christy A. Visher; O'Connell, Daniel J.; Visher, Christy A.
    RESEARCH SUMMARY This study used a randomized controlled trial approach with a sample of 400 high-risk probationers to test the hypothesis that a program incorporating principles of deterrence, graduated sanctions, and coerced abstinence would reduce recidivism rates among drug-using offenders. Bivariate and multilevel modeling strategies were implemented. Findings revealed no discernable difference across multiple drug use, probationary, and recidivism measures between those randomized into the treatment condition and those receiving standard probation. In multivariate models, probationer age, employment status, and treatment participation improved some recidivism outcomes. Programmatic and sample characteristics are discussed regarding the lack of experimental effect. POLICY IMPLICATIONS These findings suggest that in designing and implementing deterrence-informed com- munity supervision approaches, policy makers and practitioners should consider offender attributes, the addition of employment and treatment-based programs and supports, and local justice system structures. The findings of this study fit well with other emerging models of offender supervision, in particular, those that match services and programs based on offender risks and needs and those that recognize and address the heterogeneity of the offender population in developing supervision and service plans. Swift, certain, and fair supervision approaches for individuals under community supervision do not seem to be a “one-size-fits-all” strategy. Understanding for whom they work and under what conditions has not yet been determined. In the meantime, policy makers and practitioners should endeavor to understand the risks and needs of their local offender population and the community supports that are available to improve offender outcomes and increase public safety.